Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency. Human XIII is a heterotetramer.

The aim of the present study was to evaluate the contribution of factor XIIIa (FXIIIa)-positive dermal dendritic cells to formation of keloids and hypertrophic scars. The numbers of FXIIIa-positive cells were counted in the keloid, hypertrophic scar and mature scar, each of which was divided into fibrocollagenous area and superficial dermal area overlying the nodular lesion.

(Accepted June 29, 1998.) Interaction of Human Papillomavirus DNA with Factor XIIIa-positive Dermal Dendrocytes in Vulvar Lesions Naiura Vieira Pereira 1,2 , Carla Pagliari 1,2* , Elaine R. Fernandes 1 , Fernanda Guedes 1 , Mírian N. Sotto 2 and Maria Irma Seixas Duarte 1 PDF | Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets | Find, read and cite all the research you Factor XIIIa is a pan-histiocytic marker, similar to CD68. 1999-10-18 · FXIIIa is a 80 kDa subunit of the blood coagulation factor XIII, also found in cells belonging to the megakaryocyte/platelet and the monocyte/macrophage cell lineages (Adany, 1996). The aim of the present study was to evaluate the contribution of factor XIIIa (FXIIIa)-positive dermal dendritic cells to formation of keloids and hypertrophic scars. The numbers of FXIIIa-positive cells were counted in the keloid, hypertrophic scar and mature scar, each of which was divided into fibrocollagenous area and superficial dermal area overlying the nodular lesion.

The biologic significance of this finding is unknown. However, at least a subset of dermal Plasmacytoid dendritic cells, Factor XIIIa-positive dermal dendrocytes, by doublestaining technique with antiCD68 and antiiNOS antibodies in forty-three skin biopsies and anti-factor XIIIa and antiiNOS antibodies in thirty-four biopsies, comparing findings between different tissue response patterns. Background: Lymphocyte-poor graft-versus-host-reaction (GVHR) and toxic epidermal necrolysis (TEN) share some histological resemblance. In both diseases, factor-XIIIa-positive dendrocytes show some morphological changes, probably as a response to altered cytokine environment.

Factor XIIIa positive dermal dendrocytes in American tegumentary leishmaniasis cutaneous tissue response . Mirian Nacagami Sotto. mnsotto@ajato.com.br . SOTTO, Mirian Nacagami - Dendrócitos dérmicos fator XIIIa positivos na resposta tecidual cutânea da …

DF-FH often has numerous Factor XIIIa-positive macrophages in the background, in contrast Human Factor XIIIa-Positive Dermal Dendrocytes and is. Upregulated by Mast Cell confocal microscopy, GPIbα-positive cells within the.

CD1a, CD35, CD45, CD68, factor XIIIa or S-100. However, a subgroup of the cells located in the psoriatic epidermis coex-pressesHLA-DR(8).Consequently,thesecellsprobablyrepre-sent a speci¢c population of dendritic cells in human skin, distinct from other dermal dendritic cells such as Langerhans’ cells and factor XIIIa-positive cells (8).

The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells.

Factor VII. Factor VIII. Factor IX. Factor X. Factor XI. Factor XIII. Factor XIII (FXIII), or fibrin stabilizing factor, deficiency was first reported in the literature in 1960.
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Factor XIIIa Positive Control Slides , Product No. 251S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Other Notes For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com Newcomer Supply Factor XIIIa (fibrin stabilizing factor) Control Slides are for the positive immunohistochemical staining of Factor XIIIa, a blood coagulation enzyme that crosslinks fibrin. Factor XIIIa is used as a marker for fibro-histiocytic proliferations, dermal dendritic cells and to differentiate dermatofibroma from dermatofibrosarcoma. ical aid to the diagnosis of the most frequent type of EDS. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable.

Deficiency of XIII worsens clot stability and increases bleeding tendency. Immunohistochemical positive for Factor XIIIa. CD34 is usually negative in dermatofibroma but highlights the intermixed vessels and may be focally positive at the periphery of the lesion in the cellular variant (figure 17). Factor 13A usually stains the lesional cells (figure 18).
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Factor XIIIa positive cells in human skin represent a specific population of bone marrow dermal dendritic cells, distinct from Langerhans cells which share some features common to mononuclear phagocytes.

The histogenesis of Kaposi's sarcoma (KS) has been the subject of controversy, much of which has centered around whether the spindle cells of KS are derived from vascular endothelium or from lymphatics. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.

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Factor XIII, also known as fibrin stabilizing factor, is a heterodimer with the 5M Urea;10 patients had positive results with 5M Urea but normal results with MCA.

Dendritic, factor XIIIa positive cells were observed in all tissues studied, but were most numerous in skin and mucosal tissues (gastrointestinal tract, bladder). They were also observed associated with epithelial structures in lung and kidney, but were only rarely observed in liver, thyroid, testis and spleen. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Involvement in disease.

23 Jun 2008 Cerio R, Griffiths CE, Cooper KD, et al: Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin. Br J Dermatol

Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable. The biologic significance of this finding is unknown. Interaction of Human Papillomavirus DNA with Factor XIIIa-positive Dermal Dendrocytes in Vulvar Lesions Naiura Vieira Pereira 1,2 , Carla Pagliari 1,2* , Elaine R. Fernandes 1 , Fernanda Guedes 1 , Mírian N. Sotto 2 and Maria Irma Seixas Duarte 1 Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages Add photo 1 Synonyms 2 Antibodies 3 Technical Info 4 Staining Pattern 5 Expression in Normal Tissues 6 Expression in Neoplastic Entities 6.1 Benign 6.2 Benign 6.3 Intermediate/Uncertain Malignant Potential 6.4 Malignant 7 Expression in Non-Neoplastic Entities 8 Practical Uses / Panels 9 Common Pitfalls 10 References Cytoplasmic Histiocytes Fibrohistiocytes Factor XIIIa can be used in a panel Supporting: 1, Mentioning: 23 - Immunohistochemical staining for factor XIIIa, a transglutaminase, revealed a variety of positively stained cells in human fetal tissues. Factor XIIIa-positive cells were most numerous in the dermis and connective tissues.

Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin.